具有级联催化活动的纳米反应器通过同步调节Treg和巨细胞来为增强免疫疗法重新编程瘤微环境
Yuhan Fu1, Yuanyuan Zhang2, Yujie Zhang2
1Zhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.
ACS applied materials & interfaces
|September 6, 2024
概括
这项研究开发了一种双纳米输送系统,用于对抗瘤缺氧和免疫抑制,重编程巨细胞并增强免疫疗法,以更好地治疗癌症.
科学领域:
- 在瘤学瘤学.
- 纳米医学是一种纳米医学.
- 免疫学 免疫学 免疫学
背景情况:
- 瘤微环境 (TME) 中的缺氧会影响癌症免疫治疗的有效性.
- 在TME中的免疫抑制细胞进一步降低了治疗的有效性.
- 纳米颗粒在癌症治疗中具有降氧缓解和向药物输送的潜力.
研究的目的:
- 开发一个双纳米输送系统,用于在TME内针对性免疫调节.
- 为了克服缺氧诱导的免疫抑制和增强抗瘤免疫疗法.
主要方法:
- 创建了带有Pt纳米酶的空心聚多巴胺 (P@HP) 纳米载体.
- 在纳米载体中集成R848和Imatinib (IMT).
- 表面修改的纳米载体与类向M2巨细胞和调节性T (Treg) 细胞.
主要成果:
- 纳米载体选择性地向M2巨细胞和Treg细胞,将M2转移到M1表型,并减少Treg激活.
- 纳米载体的生物催化活性将H2O2转化为O2,缓解瘤缺氧.
- 增强M1巨细胞和细胞毒性T淋巴细胞的透,改善抗瘤作用,特别是在免疫检查点治疗中.
结论:
- 开发的双模式向免疫治疗策略有效地修改了TME.
- 这种方法克服了传统免疫疗法的局限性.
- 通过增强抗瘤免疫力,为癌症治疗提供新的治疗途径.
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