研究疾病持续时间对偏执性精神分裂症患者的谷氨依赖酶动态的影响
Ivan R Romash1, Iryna B Romash1, Mykhaylo M Pustovoyt1
1IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE.
概括
这项研究表明,随着时间的推移,偏执性精神分裂症患者的谷氨酶活性下降. 疾病的早期阶段 (3-5年) 呈现显著下降,随着疾病持续时间的延长而恶化,影响谷氨系统.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 精神病学是一个精神病学.
背景情况:
- 偏执性精神分裂症是一种复杂的精神疾病.
- 谷氨系统在保护细胞免受氧化应激的过程中起着至关重要的作用.
- 谷氨系统的功能障碍可能与精神分裂症的发病有关.
研究的目的:
- 在偏执性精神分裂症中纵向分析谷氨系统功能的时间动态.
- 根据疾病持续时间,调查谷氨依赖酶概况的变化.
- 在精神分裂症中识别谷氨系统抑制的关键时期.
主要方法:
- 一项纵向研究涉及300名患有偏执性精神分裂症的患者,根据疾病持续时间 (3-5,6-10,11-15,16-20和21年以上) 分为五个小组.
- 包括一个由20名患有初级精神病发作的患者组成的比较组.
- 测量了谷氨过氧化酶,谷氨减少酶和谷氨S转移酶的酶活性.
主要成果:
- 在偏执性精神分裂症患者中观察到谷氨过氧化酶,谷氨减少酶和谷氨S转移酶活性的一致降低.
- 在疾病的前3-5年内,酶活性在统计学上显著下降最为突出.
- 疾病持续时间超过21年的患者在所有三种测量酶中都显示出显著的减少.
结论:
- 在偏执性精神分裂症中,谷氨系统的功能显著受损,在疾病的早期发生显著下降.
- 长时间的疾病持续加剧了依赖谷氨的酶活动的减少.
- 了解这些时间动态为改善精神分裂症抗氧化防御的潜在治疗点提供了洞察力.
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