在移植后三年,在两个固体器官接受者身上发现艾滋病毒感染
Nancy Carolina Mopán1, Diana Carolina Plazas1, María Angélica Salinas1
1Grupo Red Donación y Trasplantes, Instituto Nacional de Salud, Bogotá, D.C., Colombia.
Biomedica : revista del Instituto Nacional de Salud
|September 6, 2024
概括
常规的器官捐赠者查可以错过人类免疫缺陷病毒 (HIV) 传播. 固体器官不能被消毒,即使进行测试也会带来风险,正如从捐赠者传播艾滋病毒到两个接受者的案例所示.
科学领域:
- 移植免疫学 移植免疫学
- 传染病传播 传染病传播
- 病毒学 病毒学
背景情况:
- 人体免疫缺陷病毒 (HIV) 对器官捐献者的常规查是标准实践.
- 尽管进行查,但通过器官移植传播艾滋病毒的风险仍然存在.
- 固体器官不能被加工或消毒以消除病原体,与某些组织不同.
研究的目的:
- 通过器官移植报告潜在的HIV传播病例.
- 为了强调在器官捐献中传染病传播的持续风险.
- 强调目前用于固体器官移植的查协议的局限性.
主要方法:
- 病例报告详细介绍器官捐赠和移植事件.
- 审查捐赠者查程序和接受者结果.
- 供体和受体的血清学检测艾滋病毒感染.
主要成果:
- 一个以前的血清阴性器官捐赠者被确定为艾滋病毒传播的来源.
- 两个器官接受者在移植后血清转化为艾滋病毒.
- 尽管遵守了常规的供体查协议,但传染发生了.
结论:
- 通过器官移植传播艾滋病毒,虽然很少发生,但仍然是一个重大问题.
- 目前的查方法不足以完全消除通过固体器官传播艾滋病毒的风险.
- 需要进一步的策略来减轻器官移植中的感染风险.
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