在以前住院的青少年中,白质结构和精神病理学之间的关联发生变化
Dana Kanel1, Nathan A Fox2, Daniel S Pine3
1Department of Human Development, University of Maryland, United States; Emotion and Development Branch, National Institute of Mental Health, United States.
Developmental cognitive neuroscience
|September 6, 2024
概括
以前住院的青少年表现出与精神病理相关的明显白质 (WM) 变化. 这些大脑的差异,特别是WM结构的差异,突出显示了年轻人具有制度化历史的独特发展途径.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 儿童精神病学 儿童精神病学
背景情况:
- 年轻人接受机构教育与心理病理学风险的增加有关.
- 在住院青少年中观察到白质 (WM) 结构变化.
- 高质量的寄养服务可能会部分降低这些风险.
研究的目的:
- 为了调查白质结构和心理病理学之间的关联,在先前住院的青少年.
- 为了检查大脑与行为之间的关联是否在制度化与非制度化的年轻人中存在差异.
- 探索制度化和寄养对青少年大脑发育和心理健康的影响.
主要方法:
- 利用扩散MRI和基于fixel的分析来评估白质结构.
- 采集了使用麦克阿瑟健康和行为问卷的青少年精神病理学数据.
- 采用一般线性模型来分析机构化状况和心理病理学之间的相互作用在大脑指标上.
主要成果:
- 以前住院的青少年在关键的大脑区域 (小脑脚,大脑体等) 显示了一般精神病理和WM结构之间的改变关联. ) 的情况.
- 在环膜和内发现了外部化行为和WM结构之间的改变关联.
- 这些发现表明,这种人群中精神病理学的独特的神经相关性.
结论:
- 大脑与行为之间的关联可能无法普遍推广,特别是在以前被关押的年轻人中.
- 制度化似乎导致不同的大脑发育,影响精神病理学的神经相关性.
- 在先前住院的青少年中,白质结构的改变有助于青春期心理病理学的独特模式.
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