儿童创伤类型与精神分裂症谱系障碍的抗精神病疗效相关:一个前性,实用性,随机对照性研究
N Mørkved1, E Johnsen2, R A Kroken2
1Mosjøen District Psychiatric Centre, Helgeland Hospital, Mosjøen, Norway; Department of Psychology, UiT The Arctic University of Norway, Tromsø, Norway.
Psychiatry research
|September 6, 2024
概括
儿童创伤亚型,特别是性虐待和身体忽视,与接受抗精神病治疗的精神分裂症谱系障碍患者的持续精神病症状有关. 这凸显了在管理这些疾病时需要创伤知情护理的需要.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 神经科学是一个神经科学.
背景情况:
- 抗精神病 (AP) 药物是精神分裂症谱系障碍 (SSD) 的标准.
- 显著的百分比的患者对AP反应不佳,表明治疗异质性.
- 儿童创伤 (CT) 在SSD中很普遍,但其对AP反应的具体影响仍未得到充分研究.
研究的目的:
- 调查不同儿童创伤 (CT) 亚型与SSD患者治疗结果之间的关联.
- 探索CT亚型是否可以解释抗精神病药物 (AP) 疗效的变化.
- 分析在AP治疗期间CT亚型和精神病症状严重程度之间的纵向关系.
主要方法:
- 该研究利用了来自伯根-斯塔万格-特朗德海姆-因斯布鲁克 (BeSt InTro) 队列的数据,其中包括98名SSD患者.
- 儿童创伤问卷-简短表格 (CTQ-SF) 评估了各种CT亚型 (身体,性,情绪虐待;身体,情绪疏忽).
- 线性混合效应 (LME) 模型分析了在52周的AP治疗中CT亚型和精神病症状 (PANSS) 之间的关系.
主要成果:
- 在特定的CT亚型和精神病症状严重程度之间发现了显著的关联.
- 性虐待和身体疏忽的较高水平与整个一年治疗期间平均精神病症状得分的增加有关.
- 这些发现表明,CT亚型对SSD中的AP治疗有效性有不同的影响.
结论:
- 儿童创伤亚型,特别是性虐待和身体疏忽,显著影响精神分裂症谱系障碍患者抗精神病治疗结果.
- 结果强调了在SSD的临床实践中评估和解决CT的重要性.
- 建议将创伤知情护理纳入SSD治疗指南,以改善患者的治疗结果.
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