终身体育活动影响帕金森病的进展
Yang Cheng Hu1, Cynthia D J Kusters2, Kimberly C Paul3
1Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Parkinsonism & related disorders
|September 6, 2024
概括
在帕金森病诊断之前从事艰苦的体力活动和竞技运动与较慢的运动和功能衰退有关. 终身体育活动可能会建立一种保护性储备,防止帕金森病的进展.
科学领域:
- 神经学 神经学
- 运动科学 运动科学
- 公共卫生 公共卫生
背景情况:
- 之前的研究表明,在帕金森病后诊断的身体活动 (PA) 会减缓运动进展.
- 这项研究调查了PD发病前终身PA对疾病进展的影响.
研究的目的:
- 为了确定终身PA是否影响帕金森病患者的运动,认知和功能衰退.
- 量化PA诊断前水平与PD进展标志物之间的关联.
主要方法:
- 利用了来自帕金森病环境和基因 (PEG) 研究的495名参与者的数据.
- 通过采访使用代谢等价物 (METs) 评估终身PA.
- 定义的PD进展时间到UPDRS-III评分≥35,Hoehn和Yahr (H&Y) 阶段≥3,MMSE下降,用Cox脆弱模型分析.
主要成果:
- 终身劳累性PA的最高四分位数 (MET-小时/周) 与达到UPDRS-III≥35 (HR=0.56) 的降低危险比率相关.
- 参与竞技运动 (任何或高水平) 显著降低了达到UPDRS-III ≥35 (HR=0.61-0.63) 的风险,并减缓了H&Y进展 (HR=0.73).
- 终身PA没有对MMSE (迷你精神状态检查) 衰退的时间产生显著影响.
结论:
- 在PD诊断之前,更高水平的终身艰苦的PA和竞技运动与较慢的运动和整体功能衰退有关.
- 终身PA可以建立一个身体储备,使帕金森病患者受益.
- 诊断前的身体活动是影响PD进展的潜在可修改因素.
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