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菌抑制Clostridium perfringens感染通过调节炎症反应,抗氧化状态,炎症酶激活和肉中的微生物平衡
Xiao Xiao1, Songke Qin2, Tiantian Cui2
1Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, China; Zhejiang Provincial Engineering Laboratory for Animal Health and Internet Technology, College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, China; Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, China; China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, China; Zhejiang Vegamax Biotechnology Co., Ltd., Huzhou 313300, China.
菌 (Bacillus licheniformis,BL) 有效地对抗肉中Clostridium perfringens (C. perfringens) 的感染. 补充BL可以改善生长,免疫力和肠道健康,减少炎症和家禽养殖中的经济损失.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 兽医医学 兽医医学 兽医医学
背景情况:
- 杆菌 (C. perfringens) 感染对动物健康构成重大威胁,并在家禽养殖业造成重大经济损失.
- 巴西菌 (Bacillus licheniformis,BL) 作为一种潜在的益生菌来缓解细菌感染.
研究的目的:
- 评估Bacillus licheniformis HJ0135 (BL) 在预防和治疗黄羽毛肉中Clostridium perfringens (C. perfringens) 感染的疗效.
- 研究BL补充剂对肉生长表现,免疫反应,肠道健康和肠道微生物群的影响.
主要方法:
- 进行了体外抗菌试验 (牛津杯,抑制率),以评估BL对C. perfringens的疗效.
- 一项体内研究涉及540只被C. perfringens挑战并接受BL治疗的肉,并分析了血清,免疫器官,状粘膜和内含量.
主要成果:
- 在实验室中,BL表现出对C. perfringens的强烈抑制作用.
- 在体内,BL补充剂显著改善了体重,平均每日增加,胸腺指数,血清免疫球蛋白和抗氧化剂,同时降低了料转化率和促炎细胞因子.
- BL缓解了关损伤,减少了促炎性细胞因子,增加了紧结蛋白表达,抑制了NLRP3炎症酶激活,并调节了部微生物群,增加了有益的短链脂肪酸.
结论:
- 细菌 licheniformis HJ0135 是一个有前途的益生菌,用于预防和治疗Clostridium perfringens引起的疾病在 brojlers.
- 通过改善生长,免疫力和肠道完整性,BL提高肉健康,为减少家禽养殖经济损失提供了可行的战略.
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