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Updated: Jun 14, 2025

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通过基因替代疗法恢复听力,用于在人类DFNB111聋的小鼠模型中多站点表达的基因

Luoying Jiang1, Shao Wei Hu1, Zijing Wang2

  • 1ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Hearing Medicine, Shanghai 200031, China; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China; Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

American journal of human genetics
|September 6, 2024
PubMed
概括

基因疗法对MPZL2基因引起的遗传性听力损失有前途. 在小鼠模型中,AAV-ie-Mpzl2治疗改善了听力,并恢复了耳细胞结构.

关键词:
在 DFNB111 里面.在MPZL2中使用MPZL2.基因治疗的基因疗法遗传性听力损失是一种遗传性听力损失.

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