慢性社会失败压力导致通过恐惧学习的社会回避
Jinah Lee1, Antonio Aubry2, Sadiyah Hanif3
1Department of Psychology, Hunter College, City University of New York, New York, NY, USA; Psychology Program, The Graduate Center, City University of New York, New York, NY, USA.
Behavioural brain research
|September 6, 2024
概括
慢性社会失败压力 (CSDS) 通过与社会目标建立恐惧关联,在小鼠中诱导社会回避. 这种恐惧条件可以被学习和灭,突出了恐惧电路在压力引起的社会退缩中的作用.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 压力研究 压力研究
背景情况:
- 慢性社会失败压力 (CSDS) 是一种与压力相关的疾病的动物模型.
- 通常情况下,CSDS会减少敏感动物的社交互动.
- 129 Sv/Ev小鼠比C57BL/6小鼠更容易受到CSDS的影响.
研究的目的:
- 调查恐惧学习在CSDS引起的社会回避中的作用.
- 检查CSDS中的社会回避是否是一种有条件的恐惧反应.
- 在易受感染的小鼠中探索社会回避的基础机制.
主要方法:
- 使用了 129 Sv/Ev 雄性小鼠,该菌株易受 CSDS 的感染.
- 评估了社会互动和避免行为.
- 采用了帕夫洛夫式的恐惧调节范式,包括二次调节.
- 通过重复的社会互动测试来研究恐惧灭绝.
主要成果:
- 被击败的129 Sv/Ev小鼠避免了CD-1小鼠,但没有同类,这表明社会化动机完好无损.
- 在CSDS期间,小鼠学会将CD-1外颜色与威胁联系起来.
- 避免行为是逐渐获得的,可以被灭.
- 第二阶段的调节导致避免空箱.
- 社会互动的变化表明了恐惧的泛化.
结论:
- 将恐惧定制为社会目标是CSDS的关键组成部分.
- 恐惧回路与CSDS中观察到的社会回避有关.
- 由CSDS诱导的社会回避是由学会的恐惧反应介导的.
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