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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
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生物医学事件因果关系提取与深度知识融合和基于Roberta的数据增强.

Lishuang Li1, Yi Xiang1, Jing Hao1

  • 1School of Computer Science and Technology, Dalian University of Technology, Dalian, 116024, China.

Methods (San Diego, Calif.)
|September 6, 2024
PubMed
概括

本研究引入了一种新的生物医学事件因果关系提取方法 (BECRE),使用深度知识融合和数据增强. 该方法增强了关系发现,解决了数据不平衡,实现了最先进的结果.

科学领域:

  • 生物医学信息学 生物医学信息学
  • 自然语言处理自然语言处理.
  • 计算生物学 计算生物学

背景情况:

  • 生物医学事件因果关系提取 (BECRE) 对于理解生物医学文本至关重要.
  • 现有的BECRE方法因功能有限和数据不平衡问题而扎.
  • 对于数据不平衡的传统过量采样方法忽视了数据多样性.

研究的目的:

  • 提出一种新的BECRE方法,以解决现有方法的局限性.
  • 加强生物医学事件之间的因果关系的提取.
  • 改善数据多样性,克服BECRE数据集中的不平衡.

主要方法:

  • 深度知识融合包括结构事件表示和实体关系路径.
  • 利用图形卷积神经网络 (GCN) 和预测张量模型进行事件表示.
  • 采用三重注意力机制来融合知识表示.
  • 对不平衡数据集实施基于罗伯塔的数据增强策略.

主要成果:

  • 拟议的方法在汉·威尔和BioCause数据集上实现了最先进的性能.
  • 深度知识融合有效地建立了生物医学事件之间的语义联系.
  • 基于Roberta的数据增强成功地解决了数据不平衡,同时促进了多样性.
关键词:
生物医学事件因果关系提取生物医学事件因果关系提取数据增强数据增强深入的知识融合融合.实体关系路径实体关系路径结构性的事件代表性.

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结论:

  • 新的BECRE方法在当前的进步中表现出卓越的性能.
  • 深度知识融合和先进的数据增强对BECRE有效.
  • 该方法为从生物医学文献中提取因果关系提供了显著的改进.