糖尿病改变了雌激素对内皮功能的保护作用,通过脂肪组织的分泌体
Melanie Raquel Martínez-Cignoni1, Agustí González-Vicens1, Andrea Morán-Costoya2
1Grup de Metabolisme Energètic i Nutrició (GMEIN), Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Baleares, Ctra. Valldemossa, km 7.5, E-07122, Palma, Balearic Islands, Spain.
Free radical biology & medicine
|September 6, 2024
概括
卵巢切除改善了肥胖,糖尿病老鼠的白脂肪组织 (WAT) 功能和分泌物分泌. 这导致内皮功能障碍减少,这表明17β-雌二醇 (E2) 在糖尿病中起着有害作用.
科学领域:
- 内分泌学 在内分泌学.
- 心血管科学 心血管科学
- 代谢综合征研究 代谢综合征研究
背景情况:
- 雌激素传统上被认为是对代谢综合征的保护性作用.
- 最近的数据挑战了雌激素在肥胖,糖尿病妇女中的心脏保护作用.
- 功能障碍的白脂肪组织 (WAT) 对糖尿病患者的心血管系统产生负面影响.
研究的目的:
- 调查17β-雌二醇 (E2) 在脂肪组织和内皮功能之间的相互作用中的作用.
- 在糖尿病模型中阐明WAT功能障碍背后的机制及其心血管后果.
主要方法:
- 使用的Zucker糖尿病脂肪 (ZDF) 雌性大鼠 (fa/fa) 接受卵巢切除术 (OVA),OVA+E2治疗或假手术.
- 评估了大动脉内皮功能,血管重塑,WAT线粒体功能,氧化应激和皮蛋白生产.
- 评估了WAT分泌物对人类静脉内皮细胞 (HUVEC) 的影响,并探索了皮菌素受体相互作用.
主要成果:
- 卵巢切除改善了WAT功能障碍,增加了肥胖,糖尿病老鼠的皮蛋白分泌.
- 这些效应与减少内皮功能障碍和主动脉炎症和HUVEC相关.
- 鉴定出阿迪波涅丁是卵巢切除术对脂肪血管轴的有益影响的关键调解剂.
结论:
- 在肥胖和糖尿病患者中,卵巢切除改善了WAT分泌和增强了内皮功能.
- 这些发现表明17β-雌二醇 (E2) 在糖尿病的背景下可能具有有害作用.
- 皮菌素在调解卵巢切除术对脂肪血管系统的积极影响方面发挥着至关重要的作用.
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