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Updated: Jun 14, 2025

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人类衍生的单克隆性自身抗体作为脑细胞蛋白型的审讯器

Matthew L Baum1, Christopher M Bartley2

  • 1Brigham and Women's Hospital, Department of Psychiatry, Boston, MA, USA; Harvard Medical School, Department of Psychiatry, Boston, MA, USA.

Trends in neurosciences
|September 6, 2024
PubMed
概括

人类衍生的单克隆性自身抗体 (HD-mAbs) 可以针对由细胞蛋白型定义的特定神经子群. 这些抗体为神经心理疾病的神经科学研究提供了一个新的工具.

关键词:
抗体工程是针对抗体的工程.自身免疫性脑炎的发生.自免疫性精神病症的精神病.人类衍生的单克隆抗体.神经电路的神经电路.精确的神经科学是精确的神经科学.

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
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Commonly used fusion techniques — electroporation,...
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