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在抗雄激素剥夺疗法后,丸激素恢复

Austin Y Ho¹, Eric V Li¹, Richard Bennett²

¹Northwestern University, Feinberg School of Medicine, Department of Urology, Chicago, IL.

Urologic oncology

|September 6, 2024

概括

在雄激素剥夺疗法 (ADT) 后,的恢复有所不同. 年龄较小和使用GnRH抗剂提高了康复率,而较长的ADT疗程与更糟糕的结果有关.

科学领域:

在瘤学瘤学.
内分泌学在内分泌学.
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

雄激素剥夺疗法 (ADT) 是前列腺癌的标准治疗方法.
在ADT后的 (T) 恢复时间可能是不可预测的.
像relugolix这样的口服GnRH对抗剂显示T恢复速度比注射型GnRH对抗剂快.

研究的目的:

为了评估患者的特征,在ADT的定义持续时间后,与丸激素恢复相关.
为了比较不同ADT药物之间的T恢复率和治疗持续时间.

主要方法:

对388名完成ADT的前列腺癌患者的回顾性分析.
治疗后评估了丸激素水平,以确定恢复 (部分:>150 ng/dl,全部:≥300 ng/dl).
多变量考克斯回归分析确定了影响T恢复的因素.

主要成果:

使用GnRH抗剂与显著更高的部分T恢复率相关 (HR=3.74,P≤0.001).
年龄较小是实现部分T恢复的关键因素 (HR为1年增长=0.96,P<0.001).
延长ADT疗程 (>12个月) 使用GnRH激动剂与较低的部分T恢复率相关 (HR=0.58,P=0.001).

结论:

在ADT后的丸激素恢复是可变的,大约16%的男性仍然是割的.
GnRH抗体治疗和年轻的患者年龄是T恢复的有利预测因素.
较长时间的ADT会对T恢复率产生负面影响.

关键词:

激素对抗剂激素对抗剂前列腺癌是什么意思前列腺癌是什么意思测试激素测试激素是什么

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