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对药物负担的态度和信念,以及帕金森病中的抑郁症
Thanh Phuong Pham Nguyen1,2,3,4, Dylan Thibault5,6,7, Ali G Hamedani8,5,6,9,7
1Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. phuongpn@pennmedicine.upenn.edu.
BMC neurology
|September 6, 2024
概括
许多患有帕金森病 (PD) 的患者愿意接受他们觉得沉重的抑郁药物. 那些担心认知障碍的人可能是抑郁症干预措施的理想候选人.
科学领域:
- 老年医学 老年医学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 建议老年人停止处方可能不合适的药物.
- 在帕金森病 (PD) 中成功的抑郁治疗干预取决于患者的态度和信仰.
- 了解患者的观点是优化PD药物管理的关键.
研究的目的:
- 检查帕金森病 (PD) 患者对药物负担和抑郁症的态度和信仰.
主要方法:
- 在福克斯洞察研究的4945名参与者中进行了一项调查,包括修订的患者对处方的态度 (rPATD) 问卷.
- 后勤回归模型被用来确定治疗不满和倾向于抑郁的预测因素.
主要成果:
- 31.6%的参与者对目前的药物不满意,87.1%的人表示愿意放弃.
- 相信药物负担很高或某些药物不适合,与不满和愿意进行抑郁症相关联.
- 在考虑治疗非运动症状的新药时,认知障碍是最令人担忧的药物不良影响.
结论:
- 患有PD的个人经常对他们的药物治疗方案感到不满,并且容易接受抑郁症的处方.
- 与认知障碍相关的药物代表了PD患者群体中抑郁症计划的潜在目标.
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