Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

205
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
205
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Human Genetics01:28

Human Genetics

549
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
549
Bulimia Nervosa01:30

Bulimia Nervosa

59
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
59
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

29
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
29
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The biocontrol potential of Streptomyces polychromogenes YKL-11 against apple replant disease: Inhibition of the growth of pathogenic Fusarium and remodelling of soil microbial flora.

Plant biology (Stuttgart, Germany)·2026
Same author

Decoding collective dynamics and complexity in nanoparticle assemblies using graph theory.

Science (New York, N.Y.)·2026
Same author

Functional diversity and specialization decoded: Implications for complex particle systems, NeuroAI, and hybrid human-AI ecosystems.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Next-generation precision medicine for pain.

Molecular psychiatry·2025
Same author

Spiking dynamics of individual neurons reflect changes in the structure and function of neuronal networks.

Nature communications·2025
Same author

Deep learning to quantify the pace of brain aging in relation to neurocognitive changes.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same journal

Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.

Translational psychiatry·2026
Same journal

Maraviroc attenuates inflammation-exacerbated cognitive and amyloid pathology in an early-stage Alzheimer's disease mouse model.

Translational psychiatry·2026
Same journal

High-order brain interactions during ketamine-induced state changes: A functional marker of response in late-life treatment-resistant depression?

Translational psychiatry·2026
Same journal

Immune-metabolic mediation of depression risk: Causal evidence from antibody and metabolite GWAS.

Translational psychiatry·2026
Same journal

DRD1 and DRD2 dopamine-sensitive neurons in the central amygdala respond differently to rewarding and aversive stimuli.

Translational psychiatry·2026
Same journal

Neuroinflammation and depression: immune-brain interface mechanisms, biomarker stratification, and therapeutic strategies.

Translational psychiatry·2026
查看所有相关文章

相关实验视频

Updated: Jun 14, 2025

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

2.2K

下一代精密药物用于预防自杀倾向.

R Bhagar1, S S Gill1,2, H Le-Niculescu1,3

  • 1Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.

Translational psychiatry
|September 6, 2024
PubMed
概括
此摘要是机器生成的。

在精神病患者中发现了针对自杀风险的新血液生物标志物. 这些生物标志物,包括SLC6A4和TINF2,为自杀的生物学和潜在的治疗点提供客观的见解.

更多相关视频

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.5K
Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

28.5K

相关实验视频

Last Updated: Jun 14, 2025

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

2.2K
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.5K
Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

28.5K

科学领域:

  • 精神病学和遗传学 精神病学和遗传学
  • 分子生物学分子生物学
  • 生物标志物发现发现

背景情况:

  • 自杀倾向是一个重要的公共卫生问题,特别是在心理健康患者中.
  • 目前的评估和治疗工作受到客观,定量措施的缺乏所阻碍.
  • 血液生物标志物为了解自杀的生物学基础提供了一个潜在的途径.

研究的目的:

  • 确定,优先考虑,验证和测试精神病患者自杀倾向的血液基因表达生物标志物.
  • 扩大对跨诊断类别的自杀性生物学基础的理解.
  • 探索已识别的生物标志物的潜在治疗干预和临床应用.

主要方法:

  • 在多个独立患者队列中进行跨诊断全基因组研究.
  • 血液基因表达生物标志物的横截面和纵向分析.
  • 整合临床措施,社会决定因素和机器学习方法.

主要成果:

  • 识别新的和已知的血液生物标志物,预测高自杀率和未来住院.
  • 最重要的生物标志物包括SLC6A4 (表达增加) 和TINF2 (表达减少).
  • 与亡相关的途径涉及,这表明自杀倾向是一种由压力驱动的衰老/死亡过程.

结论:

  • 从生物学上讲,自杀倾向可能代表一种极度压力驱动的活跃衰老/死亡形式.
  • 确定的治疗匹配包括,克洛扎宾和胺,具有性别特异性的疗效.
  • 综合生物标志物,临床数据和机器学习的综合方法对自杀性评估和治疗具有变革性的临床实用性.