一种益生菌Limosilactobacillus fermentum GR-3通过调节肠道微生物群来缓解小鼠大肠炎相关的瘤发生
Tuoyu Zhou1,2, Jingyuan Wu3, Aman Khan1
1Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, Gansu, 730000, China.
NPJ science of food
|September 6, 2024
概括
来自传统江苏的益生菌Limosilactobacillus fermentum GR-3通过减少氧化应激和炎症来对抗结肠直肠癌 (CRC). 这种有益的细菌调节肠道微生物群,降低瘤发病率,并为CRC提供了一个有前途的治疗途径.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 结肠直肠癌 (CRC) 治疗正在发展,细菌干预显示出有前途.
- 益生菌Limosilactobacillus fermentum GR-3来自传统的江苏,具有显著的抗氧化特性.
- 在GR-3中产生醇衍生物,醇-3-碳胺 (ICA) 和醇-3-酸 (IPA),为其治疗潜力做出了贡献.
研究的目的:
- 研究Limosilactobacillus fermentum GR-3作为治疗结直肠癌 (CRC) 的治疗剂的疗效.
- 阐明GR-3的抗CRC作用背后的机制,包括它对氧化应激,炎症和肠道微生物组合的影响.
主要方法:
- 使用AOM/DSS诱导的结直肠癌小鼠模型来评估GR-3的治疗效果.
- 评估了GR-3对减肥,结肠长度,直肠出血和肠道屏障完整性的影响.
- 分析了肠道微生物组组成,元基因组数据和代谢物概况,以了解GR-3的作用机制.
主要成果:
- GR-3治疗显著缓解了CRC症状,包括体重减轻和结肠缩短,同时减少了氧化应激和炎症.
- 在结肠中,GR-3殖民抑制了51.2%的瘤发病率,超过了对照组和维生素C.
- GR-3调节了肠道微生物群,增加了有益的短链脂肪酸 (SCFA) 生产者,并减少了促炎性细菌.
结论:
- 利莫西拉克托巴西勒斯发酵素GR-3通过抗氧化和抗炎机制表现出强大的抗CRC作用.
- GR-3有效地修复了肠道微生物群,增强了有益的代谢物,减少了有害的代谢物.
- GR-3是结直肠癌治疗和肠道微生物组调节的有希望的益生菌候选者.
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