Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Predicting human mRNA isoform levels from site-specific splicing kinetics <i>in silico</i>.

bioRxiv : the preprint server for biology·2026
Same author

Polycomb-mediated 3D-genome organization controls replication timing.

Science advances·2026
Same author

Privatized Health Care System in Times of Crisis: South Korea's Health Care System Response to the COVID-19 Pandemic.

International journal of social determinants of health and health services·2026
Same author

Electrochemical Strain-Release Difunctionalization of Azabicyclo-[1.1.0]butanes with Nitroarenes.

Journal of the American Chemical Society·2026
Same author

MilliMap: interactive closed-loop analysis for spatial omics.

bioRxiv : the preprint server for biology·2026
Same author

On the state of protein function prediction: a report on the fourth CAFA challenge.

bioRxiv : the preprint server for biology·2026
Same journal

Demonstration of a quantum C-NOT gate in a time-multiplexed fully reconfigurable photonic processor.

Nature communications·2026
Same journal

Nonlinear quantum light source with van der Waals ferroelectric NbOX<sub>2</sub> (X = Br, I).

Nature communications·2026
Same journal

Antagonistic histone H2A variants and autonomous heterochromatin formation shape epigenomic patterns in Arabidopsis.

Nature communications·2026
Same journal

The long tail of nitrate pollution in groundwater challenges governance of global water quality.

Nature communications·2026
Same journal

Select microbial metabolites promote tau aggregation in a murine tauopathy model.

Nature communications·2026
Same journal

Warming climate has lengthened global intense tropical cyclone seasons.

Nature communications·2026
查看所有相关文章

相关实验视频

Updated: Jun 14, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.9K

细胞内空间转录组分析工具包 (InSTAnT)

Anurendra Kumar1, Alex W Schrader2, Bhavay Aggarwal3

  • 1College of Computing, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

Nature communications
|September 6, 2024
PubMed
概括
此摘要是机器生成的。

一个新的计算工具包,InSTAnT,分析空间转录组学数据,以揭示细胞内的基因同定位模式. 这种工具有助于揭示分子关系,并为细胞下生物功能提供可测试的假设.

更多相关视频

Integrative Toolkit to Analyze Cellular Signals: Forces, Motion, Morphology, and Fluorescence
14:55

Integrative Toolkit to Analyze Cellular Signals: Forces, Motion, Morphology, and Fluorescence

Published on: March 5, 2022

3.9K
iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution
10:45

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

Published on: April 30, 2011

58.4K

相关实验视频

Last Updated: Jun 14, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.9K
Integrative Toolkit to Analyze Cellular Signals: Forces, Motion, Morphology, and Fluorescence
14:55

Integrative Toolkit to Analyze Cellular Signals: Forces, Motion, Morphology, and Fluorescence

Published on: March 5, 2022

3.9K
iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution
10:45

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

Published on: April 30, 2011

58.4K

科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 像MERFISH这样的空间转录技术提供高分辨率的蜂数据.
  • 分析这些复杂的数据需要先进的计算工具来识别亚细胞模式.

研究的目的:

  • 为了介绍细胞内空间转录组分析工具包 (InSTAnT).
  • 以单分子分辨率从空间转录组学数据中提取分子关系.

主要方法:

  • InSTAnT使用专门的统计测试和算法.
  • 该工具包检测基因对和具有细胞内和细胞间共定位模式的模块.
  • 对来自不同细胞系,物种和技术的不同数据集进行验证.

主要成果:

  • 在大脑组织中识别了细胞类型和特定区域的基因同定位.
  • 发现了反映RNA相互作用和共享亚细胞功能的细胞内空间模式.
  • 使用外部数据库和RNA相互作用数据验证的发现.

结论:

  • InSTAnT有效地从空间转录组学数据中揭示亚细胞分子关系.
  • 该工具包为分子功能和相互作用生成可测试的假设.
  • 有助于更深入地了解细胞组织和基因表达模式.