酵母的实验进化表明,尽管有剥削性的非生产者的挑战,公共产品的上调可以发展
Richard J Lindsay1, Philippa J Holder1, Mark Hewlett1
1Biosciences and Living Systems Institute, University of Exeter, Exeter, UK.
Nature communications
|September 6, 2024
概括
微生物酶生产可以被非生产者利用. 然而,酵母在强烈选择下也过度产生逆转酶,抑制竞争对手并增强自身的营养吸收.
科学领域:
- 微生物生态学 微生物生态学
- 进化生物学是进化的生物学.
- 生物化学 生物化学
背景情况:
- 微生物分泌物,就像代谢酶一样,是公共产品,生产成本高,但非生产者可以利用.
- 这可能导致生产者和人口生产率下降.
- 生产者可以根据非生产者的选择压力调整分泌水平.
研究的目的:
- 挑战在强大的选择压力下减少生产的普遍趋势.
- 研究Saccharomyces cerevisiae中逆转酶生产的进化动态.
- 为了确定机制,使得尽管竞争,生产过剩.
主要方法:
- 用Saccharomyces cerevisiae进行的进化实验.
- 类型检测分析酶活性和细胞反应.
- 竞争测试使用具有改性代谢属性的工程合成菌株.
主要成果:
- 与预期相反,即使在非生产商的强大选择压力下,反转过量生产商也在发展.
- 过度生产会增加细胞外的黑索度,通过速度效率权衡来抑制竞争对手的代谢效率.
- 过度生产者还通过诱导输送体表达来增加他们的赫索索捕获率.
结论:
- 该研究挑战了在强有力的选择下减少公共产品生产的普遍性.
- 在Saccharomyces cerevisiae中,逆转酶的过度生产是由抑制竞争对手并增强自我资源获取的机制维持的.
- 这些发现表明,在以前认为不利于公共产品生产的条件下,公共产品生产可以在进化上保持稳定.
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