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在高血压患者中,阻塞性睡眠呼吸暂停和24小时尿蛋白量化之间的关联

Miaomiao Liu¹, Mulalibieke Heizhati¹, Nanfang Li²

¹Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region "Hypertension Research Laboratory"; Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Address: No. 91 Tianchi Road, Urumqi, 830001, Xinjiang, China.

Scientific reports

|September 6, 2024

概括

阻塞性睡眠呼吸暂停 (OSA) 增加了高血压患者蛋白尿的风险. 严重的OSA与损伤的可能性更高有关,而AHI和T90是独立的风险因素.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
睡眠医学睡眠医学
心脏病学心脏病学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 和蛋白尿之间的联系尚未得到充分证实,特别是在高血压患者中,这些人患功能障碍的风险很高.
高血压是病的重要危险因素,了解像OSA这样的促成因素至关重要.

研究的目的:

研究阻塞性睡眠呼吸暂停 (OSA) 作为高血压患者蛋白尿的独立风险因素.
评估OSA严重程度,睡眠参数和蛋白尿的存在之间的关联.

主要方法:

一项涉及2106名高血压参与者的横截面研究.
参与者根据呼吸暂停-呼吸暂停指数 (AHI) 严重程度进行分类.
用多变量逻辑回归分析来评估OSA指标 (AHI,ODI,T90) 和蛋白尿 (>300 mg/24h) 之间的关联,敏感性分析排除了特定的并发症.

主要成果:

75.9%的参与者患有OSA. 与没有OSA的患者相比,患有轻度,中度和重度OSA的患者表现出蛋白尿风险增加 (OR分别为1.09,1.24,1.47;P趋势<0.05).
AHI的增加,氧气不和指数 (ODI) 和氧气和度<90% (T90) 的时间与蛋白尿的可能性更高有关.
该研究发现了一种剂量-反应关系:更严重的OSA与更高的蛋白尿风险相关.

结论:

阻塞性睡眠呼吸暂停 (OSA) 是高血压患者蛋白尿的独立风险因素.
较高的OSA严重程度,具体指的是AHI和T90,在这个人群中独立地与结构性损伤的风险增加有关.

关键词:

在高血压的高血压.阻塞性睡眠呼吸暂停症是什么蛋白质尿症是一种蛋白质尿症.

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