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在格陵兰岛上,岛上居民对COVID-19疫苗接种有强大的免疫反应

Mie Møller^1,2,3,4,5, Lennart Friis-Hansen^6,7, Nikolai Kirkby⁶

¹Institue of Health and Nature, University of Greenland, Nuuk, Greenland. mimoe@uni.gl.

Communications medicine

|September 6, 2024

概括

格陵兰人对COVID-19疫苗有强烈,持久的免疫反应,在接种疫苗后的11个月内,抗体和T细胞水平高. 这支持疫苗为大流行病做出贡献.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
流行病学流行病学

背景情况:

格陵兰的COVID-19大流行影响是温和的,可能是由于疫苗接种率很高.
评估格陵兰岛疫苗接种后的SARS-CoV-2免疫反应对于理解这种现象至关重要.

研究的目的:

为了评估在接种疫苗的格陵兰人口中SARS-CoV-2特异性免疫反应.
确定初级疫苗接种后幽默和细胞免疫的持续时间和强度.

主要方法:

在格陵兰岛接受两剂疫苗的430名成年人的观察队列研究.
测量血和唾液SARS-CoV-2高峰糖蛋白Ig抗体 (S-Ab) 的时间长达11个月.
对参与者的子集中T细胞对尖端葡萄糖蛋白的反应的评估.

主要成果:

96%的参与者在2个月后具有保护性血S-Ab水平,在11个月后增加到98%.
之前的SARS-CoV-2感染显著提高了S-Ab水平;在60岁以上的个人中观察到的减少.
所有参与者的唾液S-Ab水平都可检测,与血水平相关;在11个月后观察到强大的T细胞反应.

结论:

格陵兰人对SARS-CoV-2疫苗接种有强大而持久的幽默和细胞免疫反应.
免疫反应与接种疫苗后11个月的其他人群相似.
疫苗接种可能有助于在格陵兰岛观察到COVID-19的轻微影响.

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