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相关概念视频

lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
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清细胞细胞癌中的非编码转录组概况.

Tereza Tesarova1,2, Ondrej Fiala3,4, Milan Hora5

  • 1Toxicogenomics Unit, National Institute of Public Health, Prague, Czech Republic. tereza.tesarova@szu.cz.

Nature reviews. Urology
|September 6, 2024
PubMed
概括

非编码RNAs (ncRNAs) 是清细胞细胞癌 (ccRCC) 的生物标志物,有助于个性化治疗. 需要进一步的研究和临床试验才能将它们纳入患者护理.

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科学领域:

  • 尿瘤学 尿瘤学
  • 分子病理学分子病理学
  • 发现生物标志物的发现.

背景情况:

  • 清细胞细胞癌 (ccRCC) 是一种流行的尿道癌,发病率正在上升.
  • 识别分子生物标志物对于预测治疗反应和个性化治疗在ccRCC中至关重要.
  • 非编码RNAs (ncRNAs) 涉及ccRCC病原体,并正在作为潜在的生物标志物进行研究.

研究的目的:

  • 在清细胞细胞癌 (ccRCC) 中识别和评估非编码RNA (ncRNA) 生物标记物.
  • 探索ncRNA生物标志物与患者预后,病理特征和治疗结果的关联.
  • 评估ncRNAs在ccRCC个性化治疗选择中的潜力.

主要方法:

  • 对ccRCC组织样本进行RNA测序分析.
  • 识别失调的ncRNAs. 没有调节的ncRNAs.
  • 对ncRNA表达与临床参数和治疗反应的相关性分析.

主要成果:

  • 几种ncRNA被确定在ccRCC中失调.
  • 这些ncRNAs显示出作为预后和预测生物标志物的潜力.
  • 这些发现表明ncRNAs在ccRCC发育和进展中的作用.

结论:

  • 失调的ncRNA具有作为ccRCC的生物标志物的巨大潜力,有助于预后和治疗选择.
  • 目前,ncRNA生物标志物的临床实施受到验证和标准化挑战的限制.
  • 加快临床使用需要全面的研究和将其整合到临床试验中.