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Updated: Jun 16, 2026

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人类T细胞白血病病毒1型不成熟的Gag网格明显稳定

Martin Obr1,2, Mathias Percipalle1, Darya Chernikova1

  • 1Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria.

Nature structural & molecular biology
|September 6, 2024
PubMed
概括

人类T细胞白血病病毒1型 (HTLV-1) 组合不同于其他逆转录病毒. 结构分析显示,HTLV-1使用其N端体域进行晶格稳定,与使用C端域的其他病毒不同.

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As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...