"双阳性"多标记查结果的怀孕:加拿大安大略省的一项基于人口的研究
Kara Bellai-Dussault1,2,3, Shelley D Dougan4,5, Deshayne B Fell6,5
1School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada. kbell024@uottawa.ca.
BMC pregnancy and childbirth
|September 6, 2024
概括
在怀孕期间,罕见的双阳性查结果显著增加了早产和其他不良结果的风险,即使在排除染色体异常的情况下. 这一发现有助于为患有这些不常见查结果的患者提供咨询.
科学领域:
- 在产前查.
- 孕产妇和胎儿的医学
- 遗传学 是一个遗传学.
背景情况:
- 多重标志物查对于21型和18型三症是常见的.
- 双阳性结果很少见,但人们对其了解甚少.
- 有限的证据阻碍了这些怀孕的咨询.
研究的目的:
- 调查双重阳性查结果与不良围产期结局之间的关联.
- 提供有关双阳性查结果的改善患者咨询的证据.
主要方法:
- 基于人口的回顾性队列研究在加拿大安大略省 (2016-2021年).
- 将双重阳性结果的怀孕 (三形21/18排除) 与查阴性怀孕进行比较.
- 使用修改的Poisson回归来分析与早产和其他结果的关联.
主要成果:
- 0.2%的怀孕有双阳性结果;三位症21/18排除在374.4%的怀孕中.
- 双阳性活产儿的早产风险增加 (aRR 2.6).
- 其他不良结果的风险增加,包括其他染色体异常 (aRR 81.1).
结论:
- 双阳性查结果虽然很少见,但与早产风险增加有关.
- 这些结果与其他不良的围产期结局有关,即使排除了特定的三症.
- 研究结果支持在怀孕时需要谨慎的咨询,怀孕时有双阳性查结果.
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