终身暴露于吸烟和药物滥用可能与晚发多发性硬化症有关:基于人口的病例控制研究
Naghmeh Abbasi Kasbi1, Sajjad Ghane Ezabadi1, Kosar Kohandel1
1Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Hasan Abad Sq., Tehran, Iran.
BMC neurology
|September 6, 2024
概括
吸烟,吸毒和饮酒被确定为晚发性多发性硬化症 (LOMS) 的重要危险因素. 这项研究强调了预防性干预的必要性,因为这些物质的全球使用越来越多.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 晚期发病的多发性硬化症 (LOMS),在50岁后被诊断出来,其发病率呈上升趋势,残疾进展更快.
- 虽然吸烟与多发性硬化症的进展有关,但其在LOMS发展中的作用尚不清楚.
- 这项研究调查了吸烟,药物滥用和饮酒与LOMS风险之间的联系.
研究的目的:
- 评估终身暴露于烟草和烟斗吸烟,药物滥用和酒精消费以及患LOMS的风险之间的关联.
- 为了确定LOMS.可修改的风险因素.
- 为LOMS的预防策略提供信息.
主要方法:
- 基于人口的病例控制研究在德黑兰,伊朗.
- 利用了来自伊朗全国MS注册的数据,并进行了采访.
- 采用了千平方测试,t测试和匹配的后勤回归分析.
主要成果:
- 长期吸烟显著增加了LOMS的风险 (AOR:2.57).
- 超过20年的吸烟显示,LOMS的几率增加了3.45倍.
- 药物滥用 (阿片类药物) 和酒精消费 (葡萄酒,酒) 也与较高的LOMS风险有关.
结论:
- 吸烟,吸毒和饮酒被确定为LOMS的潜在风险因素.
- 这些发现强调了预防性干预的必要性,特别是考虑到全球趋势.
- 强调针对物质使用的公共卫生倡议对预防LOMS的重要性.
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