TNF-α多态与对肺癌敏感性的相关性:基于29项研究的元分析证据
Seyed Masoud HaghighiKian1, Ahmad Shirinzadeh-Dastgiri2, Reza Ershadi3
1Department of General Surgery, School of Medicine Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran.
BMC cancer
|September 6, 2024
概括
这项研究研究了瘤亡因子-α (TNF-α) 基因多态性和肺癌风险. TNF-α -238G>A多态表现出跨种族的多种影响,而 -308G>A多态表现出亚洲子组的保护作用.
科学领域:
- 遗传学和分子生物学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 细胞因子基因的遗传变异,例如瘤亡因子-α (TNF-α),与免疫应答调节和癌症发展有关.
- 在TNF-α基因中的特定多态性,即-308G>A和-238G>A,已被研究其与肺癌易感性的潜在关联.
研究的目的:
- 进行元分析以阐明TNF-α-308G>A和-238G>A多态性与患肺癌的风险之间的关系.
- 评估这些多态性对不同种族和组织学亚型肺癌风险的影响.
主要方法:
- 在主要的科学数据库 (PubMed,Google Scholar,Web of Science,EMBASE,CNKI) 进行了系统的文献搜索,截至2023年9月25日.
- 使用元分析技术计算几率比率 (OR) 和95%置信区间 (CI) 来评估肺癌风险.
- 统计学意义用Z测试确定,P值<0.05被认为是显著的,使用综合元分析 (CMA) 2.0软件.
主要成果:
- TNF-α -308G>A多态性与肺癌风险没有显著的总体关联,但A等位基因和AA基因型在亚洲亚组中显示出保护作用.
- 在非小细胞肺癌 (NSCLC) 中, -308G>A的A等位基因与风险增加有关.
- TNF-α -238G>A多态性揭示了一个复杂的模式:AA基因型显著增加了整体风险,亚洲人的风险增加,高加索人的保护作用. AA基因型是NSCLC的一个显著风险因素.
结论:
- 虽然TNF-α -308G>A多态性与肺癌没有显著的总体关联,但在亚洲人群中,A基因可能会提供保护.
- TNF-α -238G>A多态呈现出多样化的风险概况,在亚洲人中增加肺癌风险,同时在高加索人中提供保护.
- TNF-α -238G>A多态的AA基因型是NSCLC的重要风险因素,突出了它在肺癌发病过程中的潜在作用.
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