男性表观遗传年龄加速的潜在预测者:2D:4D指纹图案
Paulina Pruszkowska-Przybylska1, Rezvan Noroozi2,3, Joanna Rudnicka2,3
1Department of Anthropology, Faculty of Biology and Environmental Protection, University of Łódź, Łódź, Poland.
概括
具有较高的第二到第四位数比率 (2D:4D) 的男性显示出更大的产前雌激素暴露,显示出加速表观遗传衰老. 这表明产前激素水平可能会影响晚年衰老过程.
科学领域:
- 内分泌学 在内分泌学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是指老年学的学科.
背景情况:
- 第二到第四位数的比率 (2D:4D) 是产前性激素暴露的公认标志物.
- 较低的2D:4D比通常表明更高的产前雄激素化.
研究的目的:
- 调查2D:4D数字比率与DNA甲基化 (DNAm) 年龄之间的关联.
- 要确定这种关联是否依赖于性别.
主要方法:
- 使用EPIC微阵列技术对182名成年人的血液样本进行全基因组甲基化分析.
- 使用多个算法计算表观遗传年龄和表观遗传年龄加速.
- 测量手指长度以确定2D:4D比率.
主要成果:
- 与"男性"模式的男性相比,表现出"女性"左手2D:4D模式 (比率≥1) 的男性表现出更快的表观遗传年龄.
- 使用PhenoAge和DNAmTL表观遗传钟观察到这种加速.
结论:
- 男性的"女性"指纹图案 (2D: 4D ≥ 1) 与表观遗传加速年龄有关.
- 男性的产前雌激素暴露可能会影响晚年衰老过程.
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