素补充剂可以预防脏损伤,并改善高血压患者的长期预后
Yawei Zheng1,2, Yuan Fang1,2, Li Li1,2
1Nanjing University of Chinese Medicine, Nanjing, China.
Phytotherapy research : PTR
|September 7, 2024
概括
高度摄入奎尔丁可以保护高血压患者免受脏损伤并改善存活率. 这项研究表明,素补充可能是高血压治疗的有益补充,减少损伤和死亡风险.
科学领域:
- 心血管研究研究心血管研究
- 营养科学 营养科学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 高血压是造成损伤和死亡的主要危险因素.
- 奎尔塞是一种黄类化合物,已显示出潜在的抗高血压特性.
- 素对脏健康和高血压患者的长期结果的具体影响需要进一步研究.
研究的目的:
- 对高血压患者的奎尔塞丁摄入量与损伤患病率之间的关联进行调查.
- 评估氨酸补充剂对高血压患者的长期预后和生存概率的影响.
- 为了确定奎尔素摄入是否会影响损伤的特定生物标志物,如尿液微专蛋白.
主要方法:
- 利用了针对高血压患者的国家健康和营养检查调查 (NHANES) 的数据.
- 从饮食研究食品和营养素数据库 (FNDDS) 提取了醇和氨酸摄入量数据.
- 分析了来自国家卫生统计中心 (NCHS) 的死亡率数据,平均随访时间为122个月.
主要成果:
- 醇总摄入量是影响高血压中损伤患病率的一个独立因素.
- 奎尔素摄入显示出显著的保护作用,每增加10 mg/d的损伤患病率下降8% (OR=0.92,p=0.032).
- 较高的奎尔素摄入量与尿液中微专蛋白水平的降低以及死亡率降低9%有关 (HR=0.91,p=0.031).
结论:
- 在高血压患者中,高素摄入量与损伤的减少和生存概率的提高有关.
- 奎尔素补充剂可以作为一种有价值的辅助疗法,用于管理高血压及其并发症.
- 需要进一步的临床试验来证实奎尔塞丁在高血压患者群体中的治疗益处.
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