越南猪类2型环状病毒的分子进化和基因型转变
Danh Cong Lai1,2, Dung Khanh Thi Le3, Trung Huu Nguyen4
1Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.
Veterinary research communications
|September 7, 2024
概括
越南的猪肉循环病毒2型 (PCV2) 从PCV2b转变为主导的PCV2d基因型. 持续的演变和区域差异凸显了持续监测和适应性疾病管理策略的必要性.
科学领域:
- 兽医病毒学 兽医病毒学
- 分子流行病学分子流行病学
- 猪病研究研究 猪病研究
背景情况:
- 猪类循环病毒2型 (PCV2) 是一种主要的猪病原体,在全球范围内造成重大经济损失.
- 猪循环病毒相关疾病 (PCVAD) 对猪业产生影响,需要对病原体动态进行研究.
研究的目的:
- 调查2007年至2023年越南PCV2的遗传多样性和进化趋势.
- 为了确定占主导地位的PCV2基因型,并跟踪基因型随时间的变化.
- 分析越南PCV2菌株的区域变异和分子适应.
主要方法:
- 从越南养猪场中分离的47个PCV2基因组 (2022-2023) 的测序和遗传学分析.
- 当前基因组数据与历史PCV2监测数据的比较.
- 在体蛋白中氨基酸替代的分析和积极的选择压力.
主要成果:
- 在最近的隔离物中发现的PCV2d (80.85%) 和PCV2b (19.15%) 是主要的基因型.
- 遗传学分析证实了PCV2a,PCV2b,PCV2d,PCV2g和PCV2h基因型的循环.
- 在2014年左右,观察到从PCV2b转向PCV2d的显著基因型转移,而PCV2h在2012年后下降.
- 在越南北部和南部之间注意到PCV2流行病学的区域差异.
- 关键抗原区域的氨基酸替代和积极选择的证据表明正在进行的病毒适应.
结论:
- 越南PCV2d是越南的主导基因型,反映了显著的进化转变.
- 持续的分子进化和PCV2菌株的区域变异需要适应性控制策略.
- 持续的遗传监测对于有效管理越南猪群中PCV2相关疾病至关重要.
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