Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Reduced Circulating Polyamines in Polyendocrine Metabolic Ovarian Syndrome (PMOS) Patients and the Impact of Putrescine on Ovarian Function and Fertility in a Murine PMOS Model.

Biology of reproduction·2026
Same author

Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche.

Clinica chimica acta; international journal of clinical chemistry·2026
Same author

Effect of ESR1 and ESR2 polymorphisms on ovarian response in assisted reproductive technology cycles: a systematic review and meta-analysis.

Scientific reports·2026
Same author

Efficacy and Safety of Vaginal Estradiol Hemihydrate as an Adjunct to Oral Estradiol Valerate in Hormone Replacement Therapy-Frozen Embryo Transfer (HRT-FET) Cycles: A Retrospective Study.

Cureus·2026
Same author

An early-onset preeclampsia study of C19MC: DNA methylation in the spermatozoa and, DNA methylation and expression in the placental villi.

Reproductive biology·2026
Same author

Gut microbiota dysbiosis in Indian women with PCOS may be linked to metabolic and hormonal dysregulation.

Future microbiology·2026

相关实验视频

Updated: Jun 14, 2025

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
09:44

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

2.9K

综合数据驱动分析识别了与PCOS相关的潜在候选基因.

Shaini Joseph1, Krutika Patil2, Niharika Rahate1

  • 1Genetic Research Center, ICMR-National Institute for Research in Reproductive and Child Health, J.M. Street, Parel, Mumbai 400012, India.

Computational biology and chemistry
|September 7, 2024
PubMed
概括
此摘要是机器生成的。

这项研究整合了PCOS数据以识别新型候选基因,发现PROS1,C1QA和KNG1在受影响妇女中下调,提供了对多囊卵巢综合征病理生理学的见解.

关键词:
补充和凝固级联.基因优先级的排序微阵列分析分析网络分析 网络分析卵巢 卵巢 卵巢 卵巢在PCOS中,PCOS是PCOS.

更多相关视频

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
04:49

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

955
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K

相关实验视频

Last Updated: Jun 14, 2025

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
09:44

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

2.9K
Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
04:49

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

955
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K

科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 生殖内分泌学 生殖内分泌学

背景情况:

  • 多囊卵巢综合征 (PCOS) 是无排卵不育的主要原因.
  • 现有的PCOS研究已经产生了大量的数据,但病因学的理解仍然不完整.
  • 对PCOS数据的综合分析可以确定其病理生理学的新型候选基因.

研究的目的:

  • 整合PCOS的文献和基因表达数据.
  • 应用基因优先级和网络分析,用于新型候选基因发现.
  • 评估基于证据的评分来对PCOS相关基因进行排名.

主要方法:

  • 综合基于证据的方法,结合文献和基因表达数据.
  • 基因优先级和网络分析用于候选基因识别.
  • 候选基因的in silico和实验验证,包括毛囊液中的蛋白质水平分析.

主要成果:

  • 确定了大约2000个与PCOS相关的可信候选基因.
  • 在形验证证了938个参与PCOS的基因.
  • 实验验证显示PCOS患者的PROS1,C1QA和KNG1下调,而VTN表达不变.

结论:

  • 在PCOS等复杂疾病中,in silico方法有效地识别和优先考虑候选基因.
  • 这项研究通过增加PCOS相关基因的目录,为PCOS分子机制提供了更清晰的见解.
  • 这些发现突出了补充和凝血途径在PCOS病变发生过程中的作用.