在全国成年人样本中探索童年不良经历和HPV疫苗接种之间的关系
Pragya Gautam Poudel1, Elizabeth Crouch2, Mengqi Xing3
1HPV Cancer Prevention Program, St. Jude Children's Research Hospital, Memphis, TN, USA.
Child abuse & neglect
|September 7, 2024
概括
童年不良经历 (ACE) 与美国成年人免疫接种率较高的人类乳头瘤病毒 (HPV) 有关,尽管这种关联因年龄和特定的ACE类型而异. 需要持续收集数据,以了解这些模式,并预防与HPV相关的癌症.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 超过60%的美国成年人报告了不良童年经历 (ACE).
- ACE与危险健康行为和减少预防性医疗保健利用相关.
- 这可能会导致晚年慢性疾病.
研究的目的:
- 研究ACE和人类乳头瘤病毒 (HPV) 疫苗接种之间的关系.
- 在全国的美国成年人样本中分析这一关联.
主要方法:
- 利用了来自CDC行为风险因素监测系统 (BRFSS) 的2019-2022年的数据.
- 包括来自选定的州的参与者:密西西比,南卡罗来纳州,田纳西州,乔治亚州,北达科他州和阿肯色州.
- 进行了描述性,单变量和多变量回归分析,以ACE作为独立变量和HPV疫苗接种作为依赖变量.
主要成果:
- 具有4+ACE的个体在2019年,2020年和2021年更有可能报告HPV疫苗接种 (ORs1.40-2.80,p<0.05).
- 这种关联在2022年并不显著 (OR=1.54,p=0.165).
- 情绪虐待和家庭精神疾病等特定的ACE与某些年份的HPV疫苗接种有关.
结论:
- 在ACE和HPV疫苗接种之间存在普遍积极的关联,特别是在早期的研究年份.
- 2022年的调查结果没有显著意义,除了情绪虐待.
- 随着时间的推移,不同的模式需要对ACE和HPV疫苗接种进行一致的数据收集,以告知HPV相关癌症预防的干预措施.
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