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多模式磁共振对多发性硬化症患者的深灰色物质进行纵向研究

Yuhui Xu¹, Yiqiu Wei¹, Zhuowei Shi¹

¹Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Journal of neuroimmunology

|September 7, 2024

概括

疾病修饰疗法 (DMT) 对多发性硬化症 (MS) 的深灰质 (DGM) 有影响. 接受治疗的患者表现出与认知功能和残疾相关的明显的微观结构变化.

科学领域:

神经成像是一种神经成像.
神经学神经学
放射学放射学是一门学科.

背景情况:

多发性硬化症 (MS) 影响中枢神经系统,深灰质 (DGM) 完整性对功能至关重要.
疾病修饰疗法 (DMT) 在MS中越来越多地使用,但它们对DGM微观结构的具体影响仍然不清楚.

研究的目的:

通过使用定量敏感度值 (QSV) 和扩散性皮质变异成像 (DKI) 在患有或没有DMT的复发性复发性多发性硬化症 (RRMS) 患者中研究DGM微观结构的纵向变化.
评估RRMS患者的DGM微结构变化和认知缺陷之间的关联.

主要方法:

对62名接受DMT治疗的RRMS患者和30名不接受DMT治疗的RRMS患者进行了MRI扫描 (3T).
定量敏感度值 (QSV) 和DKI指标 (FA,KFA,MD,MK) 在各种DGM结构 (尾状核,杏仁体,皮质体,海马体,白色球体,乳腺体) 中测量.
在成像指标和临床分数 (EDSS,DST,SDMT,MMSE,MoCA) 之间进行了相关性分析.

主要成果:

治疗和未治疗的RRMS患者在多个DGM区域显示FA,KFA和MK的纵向增加.
在接受治疗的患者的白球体和质体中观察到平均扩散率 (MD) 的显著纵向下降.
QSV和DKI测量表明与认知和残疾评估有显著的相关性,在治疗和未治疗组之间,MD和QSV的纵向变化明显.

结论:

德米似乎影响了RRMS患者的DGM的纵向微结构变化,特别是在MD和QSV.
这些DGM的微观结构变化与MS的认知功能和整体残疾有关.
需要进一步的研究来阐明DMT对DGM完整性的精确机制.

关键词:

深灰色的物质是深灰色的物质.多模态磁共振是一种多模态磁共振.多发性硬化症是多发性硬化症.

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