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来自Hypericum elodeoides的基于菲利辛酸的美洛特和它们对抗阿尔茨海默病的影响

Jing-Dian Li1, Shou-Lun He1, Guang-Hui Wang1

  • 1Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, PR China.

Bioorganic chemistry
|September 7, 2024
PubMed
概括

鉴定出了来自Hypericum elodeoides的12种新的美罗特类. 化合物1a激活了Retinoid X受体-alpha (RXRα) 并增强了ABCA1的表达,显示出作为抗阿尔茨海默症药物的潜力.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.梅罗特类化合物是什么?视网膜X受体-α (RXRα) 是一个

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