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通过NRF2/HO-1/eNOS通路通过Ramulus Mori (Sangzhi) 类来加快糖尿病伤口愈合

Fugang Xiao¹, Shunli Rui¹, Xiaoshi Zhang¹

¹Department of Endocrinology and Metabolism, School of Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Centre, Chongqing University, Chongqing 400014, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|September 7, 2024

概括

拉穆卢斯·莫里化物 (SZ-A) 在糖尿病足 (DFU) 中表现有前途. 这项研究发现,SZ-A通过激活关键信号通路,加速糖尿病伤口愈合并保护细胞免受损伤.

科学领域:

生物化学生物化学
药理学药理学是指药理学的学科.
细胞生物学细胞生物学

背景情况:

糖尿病足 (DFU) 是糖尿病的一个严重并发症.
目前对DFU的治疗方法有局限性.
拉穆卢斯·莫里化物 (SZ-A),一种治疗2型糖尿病的口服药物,尚未研究其伤口愈合潜力.

研究的目的:

调查Ramulus Mori类化合物 (SZ-A) 在加速糖尿病伤口愈合方面的治疗潜力.
阐明SZ-A对糖尿病血管生成和细胞保护的影响背后的机制.

主要方法:

在体内研究中,使用糖尿病动物模型治疗不同剂量的SZ-A (200和400毫克/公斤).
在体外实验中使用人类静脉内皮细胞 (HUVEC) 暴露于先进的糖化终产物 (AGEs).
评估细胞增殖,迁移,管形成和氧化应激标志物.
对NRF2/HO-1/eNOS信号通路激活的分析.

主要成果:

SZ-A显著加快了糖尿病伤口愈合和血管生成,以剂量依赖的方式.
SZ-A证明了对HUVECs的细胞保护作用,防止AGE诱导的氧化应激.
在体外,SZ-A增强了HUVEC的扩散,迁移和管道形成.
SZ-A治疗激活了NRF2/HO-1/eNOS信号通路,减轻了氧化损伤.

结论:

拉穆卢斯·莫里化物 (SZ-A) 具有治疗糖尿病足的巨大潜力.
通过增强血管生成和细胞保护,SZ-A促进糖尿病伤口愈合.
这些发现支持将SZ-A等植物性疗法纳入DFU的临床实践.

关键词:

糖尿病的伤口内皮细胞是内皮细胞.在NRF2/HO-1中使用NRF2/HO-1.氧化应激是一种氧化应激.拉穆卢斯·莫里 (Sangzhi) 化物在 eNOS eNOS 中使用.

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