母乳微生物群与出生体重非常低的婴儿中正在发展的肠道微生物联盟有关
Sara Shama1, Michelle R Asbury2, Alex Kiss3
1Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada; Translational Medicine Program, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
Cell reports. Medicine
|September 7, 2024
概括
母乳微生物群在非常低出生体重 (VLBW) 的婴儿中显著影响肠道殖民. 牛奶中的特定细菌在婴儿肠道中建立,其影响因养和抗生素实践而改变.
科学领域:
- 微生物学 微生物学
- 新生儿研究新生儿研究
- 肠道微生物组研究 研究肠道微生物组
背景情况:
- 母乳含有多种细菌,但它们在极低出生体重 (VLBW) 婴儿的肠道殖民中的作用尚不清楚.
- 了解这种母婴微生物联系对于改善婴儿健康结果至关重要.
研究的目的:
- 研究母乳微生物群与VLBW婴儿的肠道微生物群之间的关系.
- 确定牛奶细菌如何殖民婴儿肠道,以及这些模式是否受到临床因素的影响.
主要方法:
- 在住院期间,分析了来自94个母婴双的422对母婴乳.
- 利用零半径操作分类学单位 (zOTU) 来追踪微生物共享.
- 研究了养习惯和抗生素使用的时间变化和影响.
主要成果:
- 牛奶细菌对VLBW婴儿肠道微生物群的贡献约为30%-40%.
- 牛奶细菌属及其肠道度之间的剂量反应关系已被证明.
- 观察到微生物共享模式是动态的,受到母乳养和抗生素的影响.
结论:
- 母乳微生物群在塑造VLBW婴儿肠道微生物群方面发挥着关键作用.
- 特定的细菌从牛奶转移到婴儿肠道,影响殖民.
- 牛奶微生物与医院实践之间的相互作用调节了这种微生物转移.
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