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Updated: Jun 14, 2025

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SGLT2 抑制剂通过抑制 CD8+ T 细胞激活促进生成以改善MASH

Wenhui Liu1, Danming You2, Jiayang Lin2

  • 1Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Endocrinology, Shenzhen Hospital, Southern Medical University, Shenzhen, China.

Cell metabolism
|September 7, 2024
PubMed
概括

-葡萄糖共载体2 (SGLT2) 抑制剂,如恩帕格利弗洛辛,通过向CD8+ T细胞,减少了与代谢功能障碍相关的脂肪肝炎 (MASH) 中的肝损伤. 这种机制涉及增加β-甲酸以抑制T细胞激活.

关键词:
BDH1BDH1BDH1BDH1BDH1BDH1BDH1BDH1BDH1BDH1CD8 (((+) T细胞是T细胞中的一个.这是一种SGLT2抑制剂.ketogenesis 是一种基因的形成.与代谢功能障碍相关的脂肪肝炎.

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