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Updated: Jun 14, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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TGF-β和RAS联合揭示了开源的增强剂以驱动转移

Jun Ho Lee1, Francisco J Sánchez-Rivera2, Lan He1

  • 1Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Cell
|September 7, 2024
PubMed
概括

转化生长因子β (TGF-β) 和RAS信号通过协调上皮细胞转移到介质细胞转移 (EMT) 和细胞外基质重塑 (ECM) 来推动肺腺癌转移. 这项研究确定了关键的染色质修饰,使这种协调的转移程序成为可能.

关键词:
一个EMT一个RAS一个SMAD在TGFβ染色体增强剂纤维化肺腺癌 肺腺癌发生转移

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