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基于微生物组的生物标志物的技术状况和未来:一个多学科的德尔菲共识

Julie Rodriguez¹, Zahra Hassani², Carolina Alves Costa Silva³

¹Pharmabiotic Research Institute, Narbonne, France.

The Lancet. Microbe

|September 7, 2024

概括

专家认为,微生物组生物标志物有前途,但需要验证的方法用于临床使用. 开发标准化,易于解释的测试是推动微生物组诊断的关键.

科学领域:

微生物组研究的研究.
生物标志物的发展发展.
临床诊断临床诊断临床诊断

背景情况:

微生物群签名与疾病和治疗反应有关.
合格的基于微生物组的生物标志物尚未进入临床实践.
人类微生物组行动联盟的目标是弥合这一差距.

研究的目的:

建立专家共识,制定合格的基于微生物组的生物标志物.
确定生物标志物资格的需求,挑战和局限性.
为未来的临床实施合作项目提供信息.

主要方法:

在307名专家中进行了Delphi调查.
通过文献审查和专家采访,制定了一个问卷.
114名专家回应了第一轮,93人完成了第二轮.

主要成果:

专家们对微生物组生物标志物在各种疾病中的潜力充满信心.
生物标志物合格的主要障碍是缺乏经过验证的分析方法.
临床实施需要配套的,经过验证的分子测试,简单的解释.

结论:

经过验证的分析方法和标准化测试对于微生物群生物标志物的合格至关重要.
需要公私合作来克服挑战,并促进临床应用.
这项调查为推进基于微生物组的诊断提供了基础.

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