在内镜粘膜切除和剖析期间对ORISE凝的不良组织反应
Ali Alipouriani1, Sarah S Elsoukkary2, Kamil Erozkan1
1Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.
概括
用于内镜手术的ORISE凝可以在结肠中引起巨细胞反应 (GCR). 这些反应可能会使结直肠病变的评估和治疗变得复杂.
科学领域:
- 胃肠病学 胃肠病学
- 结肠直肠手术 结肠直肠手术
- 病理学 病理学 病理学
背景情况:
- 提升剂 (LAs) 的粘膜下注是内镜粘膜切除和剖析的标准.
- 2018年获得FDA批准的ORISE凝因其实用特性而被广泛采用.
- 然而,ORISE凝与巨细胞反应 (GCR) 有关,可能阻碍病理学评估.
研究的目的:
- 描述ORISE凝对结直肠组织的不良影响.
- 分析ORISE凝注射后GCR的发生率和影响.
主要方法:
- 在ORISE凝注射后进行细分结肠切除的45名患者的回顾性分析 (2019-2022年).
- 病理样本的描述性分析以确定GCR和残留瘤.
主要成果:
- 在69%的样本中,ORISE凝注射在组织学上得到证实,24名患者中存在GCR (53%).
- 手术的指示包括腺癌 (31%) 和疑似恶性瘤的GCR诱导质量 (7%).
- 在18%的病例中没有残留瘤,而31%的病例患有腺癌,包括晚期瘤.
结论:
- ORISE凝经常在结肠中引起GCR,可能导致质量效应形成.
- 这些组织反应可以影响复杂结直肠病变的临床决策.
- 需要进一步的研究来了解LA诱导的组织反应的病因和临床影响.
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