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血清 taurine 通过调节由免疫微环境介导的瘤免疫逃脱来影响肺癌的进展

Tu-Liang Liang¹, Hu-Dan Pan¹, Pei-Yu Yan²

¹State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Chinese Medicine Guangdong Laboratory, Guangdong Hengqin, China.

Journal of advanced research

|September 7, 2024

概括

氨酸可以在低剂量时促进肺癌的生长,但它的效果取决于剂量和免疫状态. 年轻患者应小心饮用牛素饮料,而老年或免疫缺陷患者可能会受益.

科学领域:

在瘤学瘤学.
生物化学生物化学
免疫学免疫学免疫学

背景情况:

牛酸是一种硫酸,在信号传递,免疫功能和衰老中起作用.
在肺癌患者中观察到高氨酸水平.
氨酸对肺癌进展的确切影响及其对患者的适用性仍然不清楚.

研究的目的:

为了研究 taurine 在肺癌中的作用.
探索 taurine 影响肺癌的机制.
根据牛的作用,确定基于肺癌治疗的新策略.

主要方法:

使用肺癌小鼠模型 (C57和裸体小鼠).
采用RNA测序和稳定转染技术.
分析了129名非小细胞肺癌 (NSCLC) 患者的免疫组织化学数据.

主要成果:

低剂量牛素和牛素注入的饮料增强了肺部瘤的生长,在较高剂量时效果会减弱.
核因子红色素-2-like 1 (Nfe2l1) -反应性氧物种 (ROS) -PD-1轴是一个潜在的机制,但免疫能力显著影响氨酸的影响.
氨酸通过抑制NF-κB介导的炎症来抑制裸体小鼠的瘤生长,独立于NF2l1功能.

结论:

氨酸可以作为肺癌进展的生物标志物,这表明某些患者的预后不佳.
由于潜在的瘤促进,年轻的肺癌患者应谨慎使用含 taurine 的饮料.
牛或其饮料可能更适合老年人或免疫缺陷肺癌患者.

关键词:

双重的角色双重的角色肺癌是一种肺癌.通过NF-κB介导的炎症.在Nfe2l1-ROS-PD-1轴上氨酸 (Taurine) 是一种氨酸.

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