在急性不完整的带损伤患者中的动态功能网络连接及其与感觉运动功能障碍的关联 测量
Bingyong Xie1, Haoyu Ni1, Ying Wang2
1Department of Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Department of Spine Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
World neurosurgery
|September 7, 2024
概括
急性不完全带损伤 (AICCI) 患者显示动态功能网络连接 (dFNC) 模式发生变化. 这些dFNC变化,特别是在状态3中,与感觉运动功能障碍相关,表明dFNC是潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 系统神经科学 系统神经科学
背景情况:
- 动态功能网络连接 (dFNC) 在MRI过程中跟踪实时的大脑网络变化.
- 在急性不完整带损伤 (AICCI) 中dFNC变化的神经支尚未得到充分理解.
研究的目的:
- 在AICCI患者中研究驱动dFNC变化的神经机制.
- 在AICCI中探索dFNC时间特征和感觉运动功能障碍之间的关系.
主要方法:
- 分析了来自16名AICCI患者和16名对照组的休息状态fMRI数据.
- 独立组件分析 (ICA) 确定了全脑网络.
- 一个移动窗口方法和k-means集群的特点dFNC状态.
- 相关性分析将dFNC指标与感觉运动功能障碍得分联系起来.
主要成果:
- 在所有参与者中发现了四个不同的dFNC状态.
- 与对照组相比,AICCI患者的状态3时间和频率增加.
- AICCI患者在状态4的时间和频率下降.
- 较高的感觉运动功能障碍与增加的停留时间和状态3的时间分数相关.
结论:
- AICCI患者表现出异常的dFNC状态,时间动态发生变化.
- 在AICCI中,dFNC的时间特征与感觉运动缺陷有显著的关联.
- 在AICCI中,dFNC显示为一种敏感的生物标志物,用于检测功能性大脑变化.
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