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Noah Weingarten¹, Atul C Mehta², Marie Budev²

¹Department of Surgery, University of Pennsylvania, Philadelphia, PA.

|September 7, 2024

概括

在老年人中,单一肺移植 (SLT) 与双边肺移植 (BLT) 相比,显示了较少的短期发病率和相似的早期存活率. 然而,SLT与较差的长期存活率有关,这表明要小心选择患者进行肺移植.

科学领域:

心胸外科手术是一项心胸手术.
移植医学移植医学
老年医学老年医学

背景情况:

单个肺移植 (SLT) 经常在可能不能容忍双边肺移植 (BLT) 的老年人中进行.
之前的数据表明,SLT与BLT相比可能与更糟糕的长期结果有关.

研究的目的:

为了比较SLT与BLT的结果,特别是在年长的成年肺移植接受者 (65岁及以上) 中.

主要方法:

对移植受体科学注册数据库 (2005-2022) 的分析.
接受SLT和BLT的患者的倾向匹配.
基线特征,发病率和生存率的比较使用频率统计,卡普兰-梅尔估计和考克斯回归.

主要成果:

在9,904名患者中,4,829人接受了SLT. 倾向匹配包括每组2539名患者.
接受SLT的患者住院时间更短,再输管率更低,以及对术后透析的需求更少.
虽然早期的存活率 (30天和1年) 是可比的,但SLT与明显较低的5年存活率相关 (45.4%对53.4%),并且是5年死亡率的风险因素.

结论:

在老年人中,SLT可降低短期发病率,并可与BLT相比提供可比的早期生存率.
尽管有这些好处,但SLT与较低的长期存活率有关,这凸显了在为肺移植选择患者时需要仔细考虑的需要.

关键词:

双边肺移植双边肺移植年长的成年人.结果就是结果.一次性肺移植手术

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