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低出生体重对分阶段单心室息治疗的影响
Thibault Schaeffer1, Jannik Mertin1, Jonas Palm2
1Department of Congenital and Pediatric Heart Surgery, German Heart Center Munich, Technische Universität München, Munich, Germany.
International journal of cardiology
|September 7, 2024
概括
低出生体重显著恶化单心息的结果,增加死亡率和阻碍治疗阶段的进展. 密切监测这些易受伤害的婴儿在整个照顾过程中至关重要.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 遗传性心脏病是一种先天性心脏病.
- 外科手术的结果
背景情况:
- 单心室生理学需要复杂的,分阶段的手术息.
- 低出生体重是这些患者不良结果的潜在风险因素.
研究的目的:
- 评估低出生体重对单心室阶段性息后早期和晚期结果的影响.
- 确定低出生体重是否影响死亡率和通过息阶段的进展.
主要方法:
- 对452名接受单心室第一阶段息治疗的患者的回顾性分析.
- 患者被分为低出生体重 (<=2.5公斤) 和正常出生体重 (>2.5公斤) 组.
- 评估的结果包括死亡率,进展到随后的息阶段和整体存活率.
主要成果:
- 低出生体重患者 (8%) 的早产率和心脏外异常率更高.
- 在低出生体重组中,早期和间期死亡率明显高于低出生体重组.
- 较少的低出生体重患者达到第二阶段 (57%vs77%) 和第三阶段 (38%vs56%).
- 低出生体重患者的整体5年生存率较低 (48%vs73%).
- 低出生体重是各个子组死亡率的重要风险因素.
结论:
- 低出生体重对单心室阶段性息治疗期间和之后的生存有不利影响.
- 低出生体重的有害影响在第二阶段的缓解之后仍然存在.
- 建议在间期和之后对低出生体重婴儿提高警.
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