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脂多糖在建立炎症模型中的应用

Xiao Zhang1, Xiao Tian1, Yan Wang1

  • 1Marine College, Shandong University, Weihai, Shandong 264209, China.

International journal of biological macromolecules
|September 7, 2024
PubMed
概括

来自格拉姆阴性细菌的脂聚糖 (LPS) 触发免疫反应和炎症,使其成为创建疾病模型的关键工具. 本综述详细介绍了LPS诱导的炎症模型及其对研究的评估.

关键词:
免疫反应的免疫反应.炎症模型的炎症模型.炎症性细胞因子是可以引起炎症的.脂聚糖类糖化物 脂聚糖类糖化物这就是NF-κBB.

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Formation of Lipopolysaccharides01:19

Formation of Lipopolysaccharides

Lipopolysaccharides (LPS) are crucial components of the outer membrane of Gram-negative bacteria, serving both structural and functional roles. It contributes to membrane stability and protects bacteria from host immune responses. LPS is composed of three major regions—lipid A, a core oligosaccharide, and an O antigen. The biosynthesis and assembly of LPS involve a highly coordinated set of enzymatic reactions and transport mechanisms. Additionally, LPS is recognized as an endotoxin, triggering...