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相关概念视频

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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相关实验视频

Updated: Jun 14, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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自由甲状腺激素:方法和标准化

Zijia Ma1, Zhenni Liu1, Yuhang Deng1

  • 1National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, PR China; Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.

Clinica chimica acta; international journal of clinical chemistry
|September 7, 2024
PubMed
概括
此摘要是机器生成的。

自由甲状腺激素 (FTH) 测试缺乏标准化,免疫测试显示的可比性差. 液体染色学-并联质谱学 (LC-MS/MS) 为准确的FTH测量提供了一个精确的替代方案.

关键词:
在FT3中,FT3是FT3的类型.在FT4中,FT4是FT4的类型.免疫测试是一种免疫测试.干扰因素 干扰因素这是LC-MS/MS.标准化 标准化 标准化

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An Ex vivo Culture System to Study Thyroid Development
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An Ex vivo Culture System to Study Thyroid Development

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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

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相关实验视频

Last Updated: Jun 14, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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科学领域:

  • 临床化学 临床化学
  • 分析化学 分析化学
  • 内分泌学 在内分泌学.

背景情况:

  • 自由甲状腺激素 (FTH) 测试对于甲状腺功能评估至关重要.
  • 目前用于FTH的免疫测试方法缺乏可比性和准确性.
  • 高变化系数 (CVs) 高达21.42%突出了标准化问题.

研究的目的:

  • 审查FTH检测方法和标准化挑战.
  • 突出液体染色学-并联质谱学 (LC-MS/MS) 在FTH分析中的优势.
  • 建议LC-MS/MS作为临床FTH测试的参考或辅助方法.

主要方法:

  • 全面审查FTH检测技术,包括免疫检测和LC-MS/MS.
  • 分析FTH代谢,检测意义和测试应用.
  • 讨论超过和平衡透析等分离技术.

主要成果:

  • 针对FTH的免疫测试显示了实验室间显著的变异性 (CVs 13.82%-21.42%).
  • LC-MS/MS方法为FTH检测提供了更高的精度和准确性.
  • 自由甲状腺素的两个LC-MS/MS方法是公认的参考方法.

结论:

  • 对于可靠的临床评估,FTH测定标准化至关重要.
  • LC-MS/MS为准确和可比的FTH测量提供了一个可行的解决方案.
  • 提供了标准化FTH测试的建议,以提高临床实用性.