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老年人中FTO多态和COVID-19死亡率之间的关联:基于人口的队列研究

Jaroslav A Hubacek¹, Nadezda Capkova², Martin Bobak³

¹Institute of Clinical and Experimental Medicine, Experimental Medicine Centre, Prague, Czech Republic; Charles University, Third Department of Internal Medicine, First Faculty of Medicine, Prague, Czech Republic.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

|September 7, 2024

概括

脂肪量和肥胖相关基因 (FTO) rs17817449多态性与COVID-19死亡风险增加有关. 在高龄的高加索人中,GG同胞体的死亡风险为COVID-19的2.01倍.

科学领域:

遗传学和基因组学遗传学和基因组学
传染性疾病传染性疾病
流行病学流行病学

背景情况:

在全球范围内,COVID-19大流行已经造成了显著的死亡率.
脂肪量和肥胖相关基因 (FTO) 在RNA甲基化中起作用.
病毒核酸甲基化可以影响病毒活力,使FTO成为COVID-19结果的潜在因素.

研究的目的:

为了调查FTO基因rs17817449多态和COVID-19死亡率之间的关联.
为了确定FTO变异性是否影响老年人群中COVID-19死亡风险.

主要方法:

分析了5233名老年人 (年龄在63-87岁之间) 的基于人口的队列.
在大流行期间记录了COVID-19死亡率数据和其他原因的死亡率.
进行了FTO rs17817449多态的基因定型.

主要成果:

与幸存者 (19%) 或因其他原因死亡的人 (20%) 相比,死于COVID-19的人 (34%) 的GG同位素基因型频率显著更高.
在调整了混因素后,GG同胞体的COVID-19死亡风险增加了2.01倍 (OR=2.01,95%CI:1.19-3.41).
在FTO多态和COVID-19以外的其他原因的死亡率之间没有发现任何关联.

结论:

FTO基因变异性,特别是rs17817449多态性,是COVID-19死亡率的重要预测因素.
这一遗传因素似乎特别影响了高加索人群中COVID-19相关的死亡.

关键词:

在 COVID-19 疫情中,在FTO FTO FTO.死亡率死亡率死亡率多态性多态性多态性这就是SARS-CoV-2病毒.

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