在非小细胞肺癌患者中,能量缺口与对抗编程细胞死亡1免疫检查点抑制剂的敏感性之间的关系:ELY-2研究

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|September 7, 2024

概括

满足热量需求改善了超代谢性非小细胞肺癌患者在免疫检查点抑制剂的治疗结果. 营养干预可以提高这些患者的治疗敏感性和存活率.

科学领域:

在瘤学瘤学.
代谢过程中的代谢.
免疫治疗是一种免疫疗法.

背景情况:

以前的研究表明,增加静止能量消耗 (超能代谢) 对接受免疫检查点抑制剂 (ICI) 的转移性非小细胞肺癌 (mNSCLC) 患者的治疗结果产生负面影响.
这项研究旨在探索热量摄入量充足度对mNSCLCICI治疗疗效的影响.

研究的目的:

为了研究热量覆盖对转移性非小细胞肺癌患者接受免疫检查点抑制剂治疗的治疗灵敏度的影响.
为了确定足够的能源供应是否可以减轻超能代谢的负面预后影响.

主要方法:

用ICI治疗的mNSCLC患者的多中心数据库的回顾性分析.
基线营养评估包括间接热量计,用于休息能量消耗 (REE) 和饮食师估计的食物摄入量.
超能代谢定义为测量/理论REE≥110%;热量覆盖定义为摄入量≥90%的估计需求.

主要成果:

在162名患者中,78名 (48.1%) 超代谢. 其中,40人 (51.3%) 实现了热量覆盖 (A组),38人 (48.7%) 没有 (B组).
具有热量覆盖的高代谢患者 (A组) 与没有 (1.9个月) 的患者相比,无进展生存期 (PFS) (4.3个月) 显著更长 (HR:0.49,p=0.004).
在超代谢患者中,热量覆盖与改善的PFS (HR:0.56,p=0.048) 和整体存活 (OS) (HR:0.58,p=0.03) 独立相关.

结论:

能量供应是影响非小细胞肺癌患者免疫检查点抑制剂敏感性的关键因素.
适当的热量摄入似乎可以恢复高代谢mNSCLC患者的治疗敏感性.
一个随机试验评估早期营养干预在这个患者群体是合理的.

关键词:

基础新陈代谢的基础代谢.免疫治疗是一种免疫疗法.间接热量计是间接的热量计.肺癌是一种肺癌.幸存的生存方式

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