生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖BLa80调节慢性便秘的成年人的肠道习惯:一个多中心,随机,双盲,安慰剂控制的研究
E Salo1, D Roche2, V B Gomez-Martinez3
1Complife Group, Parc Cientı́fic de Barcelona (Edifici Clúster), Avinguda Doctor Marañón, 08028 Barcelona, Spain.
Beneficial microbes
|September 7, 2024
概括
生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖BLa80,一种益生菌补充剂,有效地改善了12周的成年人便一致性和减少了便秘症状. 这项研究强调了其作为慢性便秘安全有效治疗的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 临床营养学 临床营养学
背景情况:
- 慢性便秘影响了相当一部分成年人群,影响了他们的生活质量.
- 益生菌正在被探索用于控制便秘,因为它们有可能调节肠道微生物群并改善肠道功能.
- 生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖BLa80是一种特定的益生菌菌株,因其胃肠道益处而受到研究.
研究的目的:
- 为了评估Bifidobacterium animalis亚种的疗效. 作为慢性便秘的食品补充剂,maltodextrin中的lactis BLa80.
- 评估益生菌对便一致性,频率以及患者报告的症状和生活质量的影响.
主要方法:
- 一个多中心,随机,双盲,安慰剂对照试验.
- 46名患有慢性便秘的成年人接受了B. animalis亚种. 乳糖 BLa80 (n=23) 或安慰剂 (n=23) 在12周内.
- 结果包括每周的便计数,布里斯托尔尺度便类型,PAC-SYM,PAC-QoL和GI-QLI分数.
主要成果:
- 益生菌组在第8周和第12周表现出更大的趋势,以使便类型 (布里斯托尔类型3和4) 正常化,在统计学上显著.
- 在干预组中,便秘患者的比例在第12周下降,而在安慰剂组中增加.
- 与B. animalis亚种一起,观察到便一致性的改善和便秘症状的减少. 牛奶 BLa80 补充剂. 牛奶 BLa80 补充剂.
结论:
- 通过口服摄入B. animalis亚种. 乳糖BLa80在马尔托德克斯中12周有效改善慢性便秘患者的肠道习惯.
- 该配方证明了作为一种提高便便一致性的工具的有效性和安全性.
- 这种益生菌为治疗慢性便秘和改善患者福祉提供了一个有前途的治疗选择.
相关概念视频
Drugs for Treatment of Constipation-Predominant IBS
146
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
146
Bacterial Flora of the Large Intestine
400
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
400
Chronic Bowel Disorders: Introduction
414
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
414
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
328
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
328
Anatomy of the Intestines
71.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.6K
Inflammatory Bowel Disease V: Surgical Management
133
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
133


