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Updated: Jun 14, 2025

An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion Mobility QTOF Mass Spectrometry
11:09

An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion Mobility QTOF Mass Spectrometry

Published on: April 17, 2018

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高分辨率的四极子提高了光谱纯度,并减少了异多重化定量蛋白质组中非目标离子的干扰

Shen Zhang1, J C Yves Le Blanc2, Brett Larsen3

  • 1SCIEX, Vaughan, Ontario, L4K 4V8, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, M5G 1X5, Canada; NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan, 410075, China; Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, Hunan, 410000, China.

Analytica chimica acta
|September 7, 2024
PubMed
概括

高分辨率四极隔离通过提高光谱纯度和减少模拟光谱干扰来显著提高质谱 (MS) 蛋白质组学准确性. 这种方法可以改善的识别和量化,这对于临床应用至关重要.

关键词:
化学光谱的化学光谱高分辨率的四极管.标签上的异酸标签.量化蛋白质组学是一种定量化的蛋白质组学.频谱纯度 频谱纯度 频谱纯度

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Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue11:49

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