从大量论文和误导性发现中恢复孟德尔的随机化

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Stefan Stender^1,2, Helene Gellert-Kristensen^3,4, George Davey Smith^5,6

¹Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Stefan.stender@regionh.dk.

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概括

门德尔随机化 (MR) 研究面临质量问题. 编辑应该拒绝低价值的两样MR研究,并要求对新方法进行严格的测试,以确保科学完整性.

科学领域:

流行病学流行病学
遗传流行病学遗传流行病学
生物统计学生物统计学

背景情况:

门德尔随机化 (MR) 是流行病学中因果推理的一个关键方法.
MR 的普及导致了两个令人担忧的趋势:低质量的两样 MR (2SMR) 研究的增加和未经充分验证的新型 MR 方法的过早应用.
例如,与维生素D相关的虚假发现,需要撤回和纠正.

研究的目的:

为应对低质量的2SMR研究的扩散和新型MR方法的未经验证的应用所带来的挑战.
为编辑和同行评审提供有关MR研究趋势的指导.
维护MR作为因果推理工具的科学严谨性和可信性.

主要方法:

该研究回顾了门德尔随机化研究的当前趋势,重点关注两样 MR 和新方法应用.
它为期刊编辑和同行评审者提出了具体行动,以管理研究的涌入.
建议包括拒绝缺乏额外证据的2SMR研究,并要求对新方法进行严格的测试.

主要成果:

低质量的2SMR研究的爆炸正在压倒科学文献,并增加了最小的价值.
新型MR方法在没有足够的测试的情况下过早应用,导致误导和撤回的发现.
建议编辑拒绝仅报告2SMR发现的论文,而无需进一步支持.

结论:

严格的同行评审对于维护孟德尔随机化研究的完整性至关重要.
拒绝非贡献性2SMR研究和要求对新方法进行彻底验证是关键的步骤.
实施这些措施将有助于科学界重新获得MR的价值和可靠性,用于因果推断.

关键词:

2SMRR是什么意思流行病学流行病学门德尔的随机化非线性MR是一种非线性MR.英国生物银行维生素D 维生素D是一种维生素.

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