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Updated: Jun 14, 2025

A Time-Efficient Fluorescence Spectroscopy-Based Assay for Evaluating Actin Polymerization Status in Rodent and Human Brain Tissues
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Published on: June 3, 2021

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通过F-actin稳定在阿尔茨海默氏病中缓解突触和记忆障碍

Haseena P A1,2, Nimisha Basavaraju1,2, Mahesh Chandran3

  • 1Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, 560012, India.

Alzheimer's research & therapy
|September 7, 2024
PubMed
概括

通过稳定F-actin来恢复突触性actin完整性,可以扭转阿尔茨海默病 (AD) 模型中的记忆缺陷. 这突出了针对突触性动因作为阿尔茨海默氏症认知衰退的潜在治疗策略.

关键词:
亚马帕尔 (AMPAR) 是一个亚马帕尔 (AMPAR).在 APP/PS1 中使用.阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.在F-actin的损失.没有NMDAR,没有NMDAR.在PSD-95中,我们可以看到PSD-95.后突触密度后的突触密度.突触性动因相互作用体的作用.突触功能障碍 突触功能障碍 突触功能障碍

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